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August 30, 2010: TiGenix announces the grant of a US patent for ChondroMimetic
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9-11-Sept-10: AGA (Vienna, Austria)
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Company

TiGenix is a biomedical company that focuses on innovative local treatments for damaged and osteoarthritic joints. Based in Leuven, Belgium, TiGenix was founded in 2000 by Professor Frank P. Luyten, rheumatologist and renowned scientist and Gil Beyen MBA, bioengineer and CEO of the company since its inception.

TiGenix is built on technologies developed at the universities of Leuven and Ghent. The company’s scientific background and expertise has concentrated on the developmental biology of cartilage, bone and other connective tissues. The insights TiGenix’ scientific founders gained into the biology of cartilage have led to the development of a technology platform focused on finding solutions for damaged and diseased cartilage.

The company is exploiting the power of regenerative medicine to develop durable treatments, validated through controlled, prospective, multi-centre clinical trials. Western societies are characterized by ageing populations that place an increasing emphasis on a high quality of life and life-long mobility. As such, musculoskeletal problems represent a large and growing unmet medical need. Current therapies do not provide satisfying, long-term durable repair. TiGenix therefore believes that there is a need for more long-lasting and effective treatments for cartilage damage. The company is developing a portfolio of products which address specific musculoskeletal problems. The lead indication is cartilage damage, which is a debilitating affliction affecting the mobility and functioning of patients.

To view our company presentation, click here .



Key Milestones

2010

Grant of US patent for
ChondroMimetic

Spin-out of drug discovery platform
into Arcarios

Positive 5-year ChondroCelect
follow-up results

Commercial launch of
ChondroCelect in Europe

2009

TiGenix closes Orthomimetics
acquisition

The ChondroCelect Harvester™
receives CE mark approval

ChondroCelect 36 month data
published in the American Journal
of Sports Medicine

ChondroCelect approved in
Europe

Publication of ChondroCelect
pivotal trial results honoured
with prestigious award

TiGenix receives positive CHMP
opinion for ChondroCelect

TiGenix selects location and
secures financing for new cell
expansion facility

2008

TiGenix awarded EU grant for
participation in Treat OA

TiGenix receives 1.8 million grant
for its meniscus repair program

Clinical 3-year-data
confirm clinical benefit of
ChondroCelect

2007

Submission of a Marketing
Authorization Application for
ChondroCelect

Incorporation of TC CEF LLC

Listing on the Eurolist by
Euronext Brussels through an
Initial Public Offering, raising a
total of €46m

Strategic collaboration signed
with Fidia Advanced Biopolymers

2006

TiGenix establishes U.S.
presence

2005

IND submitted to the FDA
for the ChondroCelect trial

2004

TiGenix completes recruitment
of multinational Phase III clinical
trial for cartilage repair

2003

Closing of a second financing round
(€12 million)

2002

Start of randomized, prospective,
controlled Phase III clinical trial for
ChondroCelect

2001

TiGenix Cell Expansion Facility
operational

2000

Incorporation of TiGenix

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